Group 10 secretory phospholipase A2

BE0000070ProteinHumansPLA2G10

Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids (PubMed:12021277, PubMed:9188469). It is acted on by 5 drugs in DrugBank.

Gene name
PLA2G10
UniProtKB entry
O15496Swiss-Prot
Cellular location
Secreted
Residues / weight
165 residues · 18,153 Da
Also known as
3.1.1.4 · Group X secretory phospholipase A2 · GX sPLA2 · Phosphatidylcholine 2-acylhydrolase 10 · sPLA2-X

Resolves to

Protein
UniProtO15496UniProt namePA2GX_HUMAN
Gene
HGNCHGNC:9029NCBI Gene8399GenBank2289237GeneCardsPLA2G10
Pharmacology
IUPHAR/GtoPdb1422KEGGhsa:8399
Structure
PDB1LE6PDB1LE7PDB4UY1
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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23GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Group 10 secretory phospholipase A2, how selective are they, and which programs against it are still in active trials?

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