Hypoxanthine-guanine phosphoribosyltransferase

BE0000077ProteinHumansHPRT1

Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. It is acted on by 7 drugs in DrugBank.

Gene name
HPRT1
UniProtKB entry
P00492Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
218 residues · 24,579 Da
Also known as
2.4.2.8 · HGPRT · HGPRTase · HPRT

Resolves to

Protein
UniProtP00492UniProt nameHPRT_HUMAN
Gene
HGNCHGNC:5157NCBI Gene3251GenBank306885GeneCardsHPRT1
Pharmacology
KEGGhsa:3251
Structure
PDB1BZYPDB1D6NPDB1HMP
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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3Metabolic reactionsDrug transformations it catalyses, substrate to product
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17GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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61+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Hypoxanthine-guanine phosphoribosyltransferase, how selective are they, and which programs against it are still in active trials?

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