Tryptophan 5-hydroxylase 2

BE0000080ProteinHumansTPH2

Neuron-specific enzyme that catalyzes the conversion of L-tryptophan into 5-hydroxy-L-tryptophan, the rate-limiting step in serotonin production, using Fe(2+) as cofactor and molecular oxygen and tetrahydrobiopterin (BH4) as cosubstrates (PubMed:17905754, PubMed:19319927, PubMed:37608910). It is acted on by 3 drugs in DrugBank.

Gene name
TPH2
UniProtKB entry
Q8IWU9Swiss-Prot
Residues / weight
490 residues · 56,056 Da
Also known as
1.14.16.4 · Neuronal tryptophan hydroxylase · NTPH · Tryptophan 5-monooxygenase 2

Resolves to

Protein
UniProtQ8IWU9UniProt nameTPH2_HUMAN
Gene
HGNCHGNC:20692NCBI Gene121278GenBank27497159GeneCardsTPH2
Pharmacology
IUPHAR/GtoPdb1242KEGGhsa:121278
Structure
PDB4V06PDB7QRIPDB7WIY
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tryptophan 5-hydroxylase 2, how selective are they, and which programs against it are still in active trials?

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