Telotristat

DB14218InvestigationalSmall moleculeTryptophan Hydroxylase Inhibitor

A tryptophan hydroxylase inhibitor. Telotristat ethyl (brand name Xermelo) is a prodrug of telotristat.

Chemical structure of Telotristat
Mechanism
Curator reviewed
Formula / weight
C25H22ClF3N6O3 · 546.94 g/mol (avg)
Code names
LP-778902

Resolves to

Compound
UNII381V4FCV2ZCAS1033805-28-5ChEMBLCHEMBL2103855ChEBI177736
Clinical / RWD
RxNorm1872382ATCA16AX15
Structure
InChIKeyNCLGDOBQAWBXRA-PGRDOPGGSA-NSMILESCC1=NN(C=C1)C1=CC(Cl)=CC=C1[C@@H](OC1=NC(N)=NC(=C1)C1=CC=C(C[C@H](N)C(O)=O)C=C1)C(F)(F)F
Targets
P17752TPH1Q8IWU9TPH2

What you can answer from here — as of July 07, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action
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1Drug interactionStructured to mechanism, not free text
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1Clinical trialPhase, status and sponsor resolved per trial
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1ATC codeIncluding every combination product, plus 9 drug categories
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7+ReferencesStructured and connected to the statements they support
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Which drugs share a target with Telotristat, and which of those have an active Phase 3 trial?

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