Quinone-dependent D-lactate dehydrogenase

BE0000114ProteinEscherichia coli (strain K12)dld

Catalyzes the oxidation of D-lactate to pyruvate. It is acted on by 2 drugs in DrugBank.

Gene name
dld
UniProtKB entry
P06149Swiss-Prot
Cellular location
Cell membrane
Residues / weight
571 residues · 64,612 Da
Also known as
(R)-lactate:quinone 2-oxidoreductase · 1.1.1.28 · 1.1.5.12 · D-lactate dehydrogenase · D-LDH

Resolves to

Protein
UniProtP06149UniProt nameDLD_ECOLI
Gene
NCBI Gene946653GenBank145753
Pharmacology
KEGGecj:JW2121
Structure
PDB1F0X
Drugs

What you can answer from here — as of May 03, 2025

2DrugsApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Quinone-dependent D-lactate dehydrogenase, how selective are they, and which programs against it are still in active trials?

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