Gamma-aminobutyric acid receptor subunit rho-1

BE0000129ProteinHumansGABRR1

Rho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain (PubMed:37659407). It is acted on by 4 drugs in DrugBank.

Gene name
GABRR1
UniProtKB entry
P24046Swiss-Prot
Cellular location
Postsynaptic cell membrane
Residues / weight
479 residues · 55,883 Da
Also known as
GABA(A) receptor subunit rho-1 · GABA(C) receptor · GABAAR subunit rho-1

Resolves to

Protein
UniProtP24046UniProt nameGBRR1_HUMAN
Gene
HGNCHGNC:4090NCBI Gene2569GenBank182911GeneCardsGABRR1
Pharmacology
KEGGhsa:2569
Structure
PDB8OP9PDB8OQ6PDB8OQ7
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Gamma-aminobutyric acid receptor subunit rho-1, how selective are they, and which programs against it are still in active trials?

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