Succinate-semialdehyde dehydrogenase, mitochondrial

BE0000152ProteinHumansALDH5A1

Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). It is acted on by 6 drugs in DrugBank.

Gene name
ALDH5A1
UniProtKB entry
P51649Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
535 residues · 57,214 Da
Also known as
1.2.1.24 · Aldehyde dehydrogenase family 5 member A1 · NAD(+)-dependent succinic semialdehyde dehydrogenase · SSADH

Resolves to

Protein
UniProtP51649UniProt nameSSDH_HUMAN
Gene
HGNCHGNC:408NCBI Gene7915GenBank3766467GeneCardsALDH5A1
Pharmacology
IUPHAR/GtoPdb2466KEGGhsa:7915
Structure
PDB2W8NPDB2W8OPDB2W8P
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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30+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Succinate-semialdehyde dehydrogenase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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