Mitochondrial peptide methionine sulfoxide reductase

BE0000170ProteinHumansMSRA

Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. It is acted on by 2 drugs in DrugBank.

Gene name
MSRA
UniProtKB entry
Q9UJ68Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
235 residues · 26,132 Da
Also known as
1.8.4.11 · Peptide Met(O) reductase · Peptide-methionine (S)-S-oxide reductase · PMSR · Protein-methionine-S-oxide reductase

Resolves to

Protein
UniProtQ9UJ68UniProt nameMSRA_HUMAN
Gene
HGNCHGNC:7377NCBI Gene4482GenBank6136945GeneCardsMSRA
Pharmacology
KEGGhsa:4482
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Mitochondrial peptide methionine sulfoxide reductase, how selective are they, and which programs against it are still in active trials?

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