Bifunctional glutamate/proline--tRNA ligase

BE0000188ProteinHumansEPRS1

Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. It is acted on by 7 drugs in DrugBank.

Gene name
EPRS1
UniProtKB entry
P07814Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
1,512 residues · 170,590 Da
Also known as
Bifunctional aminoacyl-tRNA synthetase · Cell proliferation-inducing gene 32 protein · EPRS · GLNS · Glutamatyl-prolyl-tRNA synthetase

Resolves to

Protein
UniProtP07814UniProt nameSYEP_HUMAN
Gene
HGNCHGNC:3418NCBI Gene2058GenBank31958GeneCardsEPRS1
Pharmacology
KEGGhsa:2058
Structure
PDB1FYJPDB4HVCPDB4K86
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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8Pfam domainsDomain architecture mapped to Pfam families and clans
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37+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Bifunctional glutamate/proline--tRNA ligase, how selective are they, and which programs against it are still in active trials?

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