NEDD8-activating enzyme E1 regulatory subunit

BE0000202ProteinHumansNAE1

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. It is acted on by 2 drugs in DrugBank.

Gene name
NAE1
UniProtKB entry
Q13564Swiss-Prot
Cellular location
Cell membrane
Residues / weight
534 residues · 60,246 Da
Also known as
Amyloid beta precursor protein-binding protein 1, 59 kDa · Amyloid protein-binding protein 1 · APP-BP1 · APPBP1 · Proto-oncogene protein 1

Resolves to

Protein
UniProtQ13564UniProt nameULA1_HUMAN
Gene
HGNCHGNC:621NCBI Gene8883GenBank1314560GeneCardsNAE1
Pharmacology
KEGGhsa:8883
Structure
PDB1R4MPDB1R4NPDB1TT5
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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21+ReferencesStructured and connected to the statements they support
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Which compounds in development act on NEDD8-activating enzyme E1 regulatory subunit, and which indications are they being tested in?

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