Leucine--tRNA ligase, mitochondrial

BE0000204ProteinHumansLARS2

Catalyzes the attachment of leucine to its cognate tRNA. It is acted on by 3 drugs in DrugBank.

Gene name
LARS2
UniProtKB entry
Q15031Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
903 residues · 101,975 Da
Also known as
6.1.1.4 · KIAA0028 · Leucyl-tRNA synthetase · LeuRS

Resolves to

Protein
UniProtQ15031UniProt nameSYLM_HUMAN
Gene
HGNCHGNC:17095NCBI Gene23395GenBank40788954GeneCardsLARS2
Pharmacology
KEGGhsa:23395
Drugs

What you can answer from here — as of September 03, 2024

3DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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1GO termFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Leucine--tRNA ligase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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