Asparagine synthetase [glutamine-hydrolyzing]

BE0000219ProteinHumansASNS

Catalyzes the ATP-dependent synthesis of L-asparagine from L-aspartate, using L-glutamine as a source of nitrogen (PubMed:2564390, PubMed:2573597). It is acted on by 5 drugs in DrugBank.

Gene name
ASNS
UniProtKB entry
P08243Swiss-Prot
Residues / weight
561 residues · 64,369 Da
Also known as
3.5.1.2 · 6.3.5.4 · Cell cycle control protein TS11 · Glutamine-dependent asparagine synthetase · TS11

Resolves to

Protein
UniProtP08243UniProt nameASNS_HUMAN
Gene
HGNCHGNC:753NCBI Gene440GenBank179100GeneCardsASNS
Pharmacology
KEGGhsa:440
Structure
PDB6GQ3PDB8SUEPDB9B6C
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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27+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Asparagine synthetase [glutamine-hydrolyzing], how selective are they, and which programs against it are still in active trials?

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