Pyrroline-5-carboxylate reductase 1, mitochondrial

BE0000225ProteinHumansPYCR1

Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate to L-proline using NAD(P)H (PubMed:16730026, PubMed:19648921, PubMed:23024808, PubMed:28258219). It is acted on by 3 drugs in DrugBank.

Gene name
PYCR1
UniProtKB entry
P32322Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
319 residues · 33,360 Da
Also known as
1.5.1.2 · P5C reductase 1 · P5CR 1

Resolves to

Protein
UniProtP32322UniProt nameP5CR1_HUMAN
Gene
HGNCHGNC:9721NCBI Gene5831GenBank189498GeneCardsPYCR1
Pharmacology
KEGGhsa:5831
Structure
PDB2GERPDB2GR9PDB2GRA
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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19+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Pyrroline-5-carboxylate reductase 1, mitochondrial, how selective are they, and which programs against it are still in active trials?

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