Tyrosine--tRNA ligase, cytoplasmic

BE0000230ProteinHumansYARS1

Tyrosine--tRNA ligase that catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (Probable) (PubMed:25533949). It is acted on by 8 drugs in DrugBank.

Gene name
YARS1
UniProtKB entry
P54577Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
528 residues · 59,143 Da
Also known as
6.1.1.1 · Tyrosyl-tRNA synthetase · TyrRS · YARS

Resolves to

Protein
UniProtP54577UniProt nameSYYC_HUMAN
Gene
HGNCHGNC:12840NCBI Gene8565GenBank1184699GeneCardsYARS1
Pharmacology
KEGGhsa:8565
Structure
PDB1N3LPDB1NTGPDB1Q11
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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22+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tyrosine--tRNA ligase, cytoplasmic, how selective are they, and which programs against it are still in active trials?

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