Microsomal triglyceride transfer protein large subunit

BE0000232ProteinHumansMTTP

Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PubMed:15897609, PubMed:16478722, PubMed:22236406, PubMed:23475612, PubMed:25108285, PubMed:26224785, PubMed:8876250, PubMed:8939939). It is acted on by 8 drugs in DrugBank.

Gene name
MTTP
UniProtKB entry
P55157Swiss-Prot
Cellular location
Endoplasmic reticulum
Residues / weight
894 residues · 99,350 Da
Also known as
MTP

Resolves to

Protein
UniProtP55157UniProt nameMTP_HUMAN
Gene
HGNCHGNC:7467NCBI Gene4547GenBank414669GeneCardsMTTP
Pharmacology
KEGGhsa:4547
Structure
PDB6I7SPDB8EOJ
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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33+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Microsomal triglyceride transfer protein large subunit, how selective are they, and which programs against it are still in active trials?

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