Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside hesperidin, is the predominant flavonoid in lemons and oranges.
- Mechanism
- Curator reviewed
Hesperetin reduces or inhibits the activity of acyl-coenzyme A:cholesterol acyltransferase genes (ACAT1 and ACAT2) and it reduces microsomal triglyceride transfer protein (MTP) activity. Hesperetin also seems to upregulate the LDL receptor. This leads to the reduced assembly and secretion of apoB-containing lipoproteins and enhanced reuptake of those lipoproteins, thereby lowering cholesterol levels.
- Primary indication
- For lowering cholesterol and, possibly, otherwise favorably affecting lipids.Curator reviewed
- Formula / weight
- C16H14O6 · 302.2788 g/mol (avg)
- Also known as
- Hesperitin
- Code names
- FEMA NO. 4313 · NSC-57654
Resolves to
AIONOLUJZLIMTK-AWEZNQCLSA-NSMILESCOC1=C(O)C=C(C=C1)[C@@H]1CC(=O)C2=C(O)C=C(O)C=C2O1What you can answer from here — as of September 23, 2026
Which drugs share a target with Hesperetin, and which of those have an active Phase 3 trial?
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