Transcobalamin-1

BE0000238ProteinHumansTCN1

Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach. It is acted on by 3 drugs in DrugBank.

Gene name
TCN1
UniProtKB entry
P20061Swiss-Prot
Cellular location
Secreted
Residues / weight
433 residues · 48,206 Da
Also known as
Haptocorrin · HC · Protein R · TC I · TC-1

Resolves to

Protein
UniProtP20061UniProt nameTCO1_HUMAN
Gene
HGNCHGNC:11652NCBI Gene6947GenBank307479GeneCardsTCN1
Pharmacology
KEGGhsa:6947
Structure
PDB4KKIPDB4KKJ
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Transcobalamin-1, how selective are they, and which programs against it are still in active trials?

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