4-aminobutyrate aminotransferase, mitochondrial

BE0000253ProteinHumansABAT

Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively (PubMed:10407778, PubMed:15528998). It is acted on by 18 drugs in DrugBank.

Gene name
ABAT
UniProtKB entry
P80404Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
500 residues · 56,438 Da
Also known as
(S)-3-amino-2-methylpropionate transaminase · 2.6.1.19 · GABA aminotransferase · GABA transaminase · GABA-AT

Resolves to

Protein
UniProtP80404UniProt nameGABT_HUMAN
Gene
HGNCHGNC:23NCBI Gene18GenBank602705GeneCardsABAT
Pharmacology
IUPHAR/GtoPdb2464KEGGhsa:18
Drugs

What you can answer from here — as of September 07, 2019

18DrugsApproved to experimental, with action, bond type and pharmacological action
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15GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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56+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 4-aminobutyrate aminotransferase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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