Retinol-binding protein 3

BE0000255ProteinHumansRBP3

Mediates the transport of 11-cis- and all-trans-retinoids between the retinal pigment epithelium (RPE) and photoreceptors, facilitating retinoid exchange required for the visual cycle. It is acted on by 3 drugs in DrugBank.

Gene name
RBP3
UniProtKB entry
P10745Swiss-Prot
Cellular location
Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix
Residues / weight
1,247 residues · 135,361 Da
Also known as
Interphotoreceptor retinoid-binding protein · Interstitial retinol-binding protein · IRBP

Resolves to

Protein
UniProtP10745UniProt nameRET3_HUMAN
Gene
HGNCHGNC:9921NCBI Gene5949GenBank186541GeneCardsRBP3
Pharmacology
KEGGhsa:5949
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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21+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Retinol-binding protein 3, how selective are they, and which programs against it are still in active trials?

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