Lapachone

DB11948InvestigationalSmall molecule

Lapachone has been used in trials studying the treatment of Cancer, Carcinoma, Advanced Solid Tumors, Head and Neck Neoplasms, and Carcinoma, Squamous Cell.

Chemical structure of Lapachone
Formula / weight
C15H14O3 · 242.274 g/mol (avg)
Code names
ARQ-501 · HK-660S · MB-12066 · NSC-26326 · NSC-629749

Resolves to

Compound
UNII6N4FA2QQ6ACAS4707-32-8ChEMBLCHEMBL15192ChEBI10429PubChem3885KEGGC10367
Structure
InChIKeyQZPQTZZNNJUOLS-UHFFFAOYSA-NSMILESCC1(C)CCC2=C(O1)C1=CC=CC=C1C(=O)C2=O
Targets
P11387TOP1P10745RBP3

What you can answer from here — as of January 29, 2025

2Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
14Drug interactionsStructured to mechanism, not free text
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11Clinical trialsPhase, status and sponsor resolved per trial
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1+ReferenceStructured and connected to the statements they support
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Which drugs share a target with Lapachone, and which of those have an active Phase 3 trial?

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