Cytosolic purine 5'-nucleotidase

BE0000261ProteinHumansNT5C2

Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates (PubMed:10092873, PubMed:12907246, PubMed:1659319, PubMed:9371705). It is acted on by 4 drugs in DrugBank.

Gene name
NT5C2
UniProtKB entry
P49902Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
561 residues · 64,969 Da
Also known as
3.1.3.5 · 3.1.3.99 · cN-II · Cytosolic 5'-nucleotidase II · Cytosolic IMP/GMP-specific 5'-nucleotidase

Resolves to

Protein
UniProtP49902UniProt name5NTC_HUMAN
Gene
HGNCHGNC:8022NCBI Gene22978GenBank633071GeneCardsNT5C2
Pharmacology
KEGGhsa:22978
Structure
PDB2J2CPDB2JC9PDB2JCM
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cytosolic purine 5'-nucleotidase, how selective are they, and which programs against it are still in active trials?

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