Arginase-1

BE0000286ProteinHumansARG1

Catalyzes the final step of the urea cycle by hydrolyzing L-arginine into urea, a nitrogenous waste product, and L-ornithine, a precursor to proline and polyamines; the urea cycle occurs primarily in the liver and, to... It is acted on by 16 drugs in DrugBank.

Gene name
ARG1
UniProtKB entry
P05089Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
322 residues · 34,735 Da
Also known as
3.5.3.1 · Liver-type arginase · Type I arginase

Resolves to

Protein
UniProtP05089UniProt nameARGI1_HUMAN
Gene
HGNCHGNC:663NCBI Gene383GenBank178995GeneCardsARG1
Pharmacology
IUPHAR/GtoPdb1244KEGGhsa:383
Structure
PDB1WVAPDB1WVBPDB2AEB
Drugs

What you can answer from here — as of September 07, 2019

16DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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42+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Arginase-1, how selective are they, and which programs against it are still in active trials?

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