S-adenosylmethionine synthase isoform type-2

BE0000304ProteinHumansMAT2A

Catalyzes the formation of S-adenosylmethionine from methionine and ATP. It is acted on by 2 drugs in DrugBank.

Gene name
MAT2A
UniProtKB entry
P31153Swiss-Prot
Residues / weight
395 residues · 43,660 Da
Also known as
2.5.1.6 · AdoMet synthase 2 · AMS2 · MAT 2 · MAT-II

Resolves to

Protein
UniProtP31153UniProt nameMETK2_HUMAN
Gene
HGNCHGNC:6904NCBI Gene4144GenBank36327GeneCardsMAT2A
Pharmacology
IUPHAR/GtoPdb3341KEGGhsa:4144
Structure
PDB2P02PDB4KTTPDB4KTV
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on S-adenosylmethionine synthase isoform type-2, how selective are they, and which programs against it are still in active trials?

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