Polyunsaturated fatty acid lipoxygenase ALOX15

BE0000309ProteinHumansALOX15

Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators (PubMed:17052953, PubMed:1944593, PubMed:24282679, PubMed:25293588, PubMed:32404334, PubMed:8334154). It is acted on by 11 drugs in DrugBank.

Gene name
ALOX15
UniProtKB entry
P16050Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
662 residues · 74,804 Da
Also known as
12-LOX · 12/15-lipoxygenase · 15-LOX · 15-LOX-1 · Arachidonate 12-lipoxygenase, leukocyte-type

Resolves to

Protein
UniProtP16050UniProt nameLOX15_HUMAN
Gene
HGNCHGNC:433NCBI Gene246GenBank307135GeneCardsALOX15
Pharmacology
IUPHAR/GtoPdb1388KEGGhsa:246
Drugs

What you can answer from here — as of September 03, 2024

11DrugsApproved to experimental, with action, bond type and pharmacological action
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2Metabolic reactionsDrug transformations it catalyses, substrate to product
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24GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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31+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Polyunsaturated fatty acid lipoxygenase ALOX15, how selective are they, and which programs against it are still in active trials?

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