Alanine--glyoxylate aminotransferase

BE0000316ProteinHumansAGXT

Peroxisomal aminotransferase that catalyzes the transamination of glyoxylate to glycine and contributes to the glyoxylate detoxification (PubMed:10960483, PubMed:12777626, PubMed:23229545, PubMed:24055001, PubMed:26149463). It is acted on by 7 drugs in DrugBank.

Gene name
AGXT
UniProtKB entry
P21549Swiss-Prot
Cellular location
Peroxisome
Residues / weight
392 residues · 43,010 Da
Also known as
2.6.1.44 · AGT · AGT1 · Serine--pyruvate aminotransferase · SPAT

Resolves to

Protein
UniProtP21549UniProt nameAGT1_HUMAN
Gene
HGNCHGNC:341NCBI Gene189GenBank36582GeneCardsAGXT
Pharmacology
KEGGhsa:189
Structure
PDB1H0CPDB1J04PDB2YOB
Drugs

What you can answer from here — as of September 03, 2024

7DrugsApproved to experimental, with action, bond type and pharmacological action
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4Clinical trialsTrials of drugs acting on it, by phase and status
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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49+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Alanine--glyoxylate aminotransferase, how selective are they, and which programs against it are still in active trials?

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