GMP synthase [glutamine-hydrolyzing]

BE0000321ProteinHumansGMPS

Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate. It is acted on by 4 drugs in DrugBank.

Gene name
GMPS
UniProtKB entry
P49915Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
693 residues · 76,715 Da
Also known as
6.3.5.2 · Glutamine amidotransferase · GMP synthetase

Resolves to

Protein
UniProtP49915UniProt nameGUAA_HUMAN
Gene
HGNCHGNC:4378NCBI Gene8833GenBank595410GeneCardsGMPS
Pharmacology
KEGGhsa:8833
Structure
PDB2VPIPDB2VXO
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
3Metabolic reactionsDrug transformations it catalyses, substrate to product
Sign in
1GO termFunction, process and component, as structured annotations
Sign in
3Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
23+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on GMP synthase [glutamine-hydrolyzing], how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In