Cystathionine beta-synthase

BE0000323ProteinHumansCBS

Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. It is acted on by 10 drugs in DrugBank.

Gene name
CBS
UniProtKB entry
P35520Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
551 residues · 60,586 Da
Also known as
4.2.1.22 · Beta-thionase · Serine sulfhydrase

Resolves to

Protein
UniProtP35520UniProt nameCBS_HUMAN
Gene
HGNCHGNC:1550NCBI Gene875GenBank388716GeneCardsCBS
Pharmacology
IUPHAR/GtoPdb1443KEGGhsa:875
Structure
PDB1JBQPDB1M54PDB4COO
Drugs

What you can answer from here — as of September 07, 2019

10DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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23GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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80+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cystathionine beta-synthase, how selective are they, and which programs against it are still in active trials?

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