Glutamate receptor ionotropic, kainate 1

BE0000346ProteinHumansGRIK1

Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. It is acted on by 11 drugs in DrugBank.

Gene name
GRIK1
UniProtKB entry
P39086Swiss-Prot
Cellular location
Cell membrane
Residues / weight
918 residues · 103,980 Da
Also known as
EAA3 · Excitatory amino acid receptor 3 · GluK1 · GluR-5 · GLUR5

Resolves to

Protein
UniProtP39086UniProt nameGRIK1_HUMAN
Gene
HGNCHGNC:4579NCBI Gene2897GenBank455448GeneCardsGRIK1
Pharmacology
IUPHAR/GtoPdb450KEGGhsa:2897
Structure
PDB2ZNSPDB2ZNTPDB2ZNU
Drugs

What you can answer from here — as of September 07, 2019

11DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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8GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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25+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glutamate receptor ionotropic, kainate 1, how selective are they, and which programs against it are still in active trials?

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