Butabarbital is a barbiturate drug used as a sedative and hypnotic. Butabarbital, or Butisol, is a fast onset barbiturate with short duration of action compared to other barbiturates.
- Mechanism
- Curator reviewed · 6 references
Barbiturates like butabarbital potentiate GABA-A receptors and inhibit receptors for neuronal acetylcholine, and kainate. GABA-A receptors are predominantly on the post-synaptic membrane, and upon activation, open chloride channels to hyperpolarize the neuron and decreased firing rate. Potentiation of GABAergic neurons produces sedation. Inhibition of neuronal acetylcholine receptors and glutamate receptors of the kainate subtype desensitize their respective neurons, producing sedation.
- Primary indication
- Butabarbital is indicated for use as a sedative or hypnotic.Curator reviewed · 2 structured indications
- Formula / weight
- C10H16N2O3 · 212.2456 g/mol (avg)
- First approval
- Canada, 1982 · United States, 1939
- Also known as
- Secbutabarbital
Resolves to
ZRIHAIZYIMGOAB-UHFFFAOYSA-NSMILESCCC(C)C1(CC)C(=O)NC(=O)NC1=OWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Butabarbital, and which of those have an active Phase 3 trial?
Create a free account or log in to explore the full data card.
Create Account