Potassium-transporting ATPase alpha chain 1

BE0000349ProteinHumansATP4A

The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. It is acted on by 16 drugs in DrugBank.

Gene name
ATP4A
UniProtKB entry
P20648Swiss-Prot
Cellular location
Apical cell membrane
Residues / weight
1,035 residues · 114,118 Da
Also known as
7.2.2.19 · Gastric H(+)/K(+) ATPase subunit alpha · Proton pump

Resolves to

Protein
UniProtP20648UniProt nameATP4A_HUMAN
Gene
HGNCHGNC:819NCBI Gene495GenBank561634GeneCardsATP4A
Pharmacology
IUPHAR/GtoPdb849KEGGhsa:495
Drugs

What you can answer from here — as of September 07, 2019

16DrugsApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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6Pfam domainsDomain architecture mapped to Pfam families and clans
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49+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Potassium-transporting ATPase alpha chain 1, how selective are they, and which programs against it are still in active trials?

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