Acid-sensing ion channel 1

BE0000353ProteinHumansASIC1

Forms voltage-independent, pH-gated trimeric sodium channels that act as postsynaptic excitatory receptors in the nervous system, playing a crucial role in regulating synaptic plasticity, learning, and memory (PubMed:21036899, PubMed:32915133, PubMed:34319232). It is acted on by 2 drugs in DrugBank.

Gene name
ASIC1
UniProtKB entry
P78348Swiss-Prot
Cellular location
Cell membrane
Residues / weight
528 residues · 59,909 Da
Also known as
ACCN2 · Amiloride-sensitive cation channel 2, neuronal · ASIC1 · BNAC2 · Brain sodium channel 2

Resolves to

Protein
UniProtP78348UniProt nameASIC1_HUMAN
Gene
HGNCHGNC:100NCBI Gene41GenBank1871168GeneCardsASIC1
Pharmacology
IUPHAR/GtoPdb684KEGGhsa:41
Structure
PDB6L6IPDB6L6NPDB7CFS
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Acid-sensing ion channel 1, how selective are they, and which programs against it are still in active trials?

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