Voltage-dependent P/Q-type calcium channel subunit alpha-1A

BE0000356ProteinHumansCACNA1A

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell... It is acted on by 8 drugs in DrugBank.

Gene name
CACNA1A
UniProtKB entry
O00555Swiss-Prot
Cellular location
Cell membrane
Residues / weight
2,506 residues · 282,562 Da
Also known as
BI · Brain calcium channel I · CACH4 · CACN3 · CACNL1A4

Resolves to

Protein
UniProtO00555UniProt nameCAC1A_HUMAN
Gene
HGNCHGNC:1388NCBI Gene773GenBank2213913GeneCardsCACNA1A
Pharmacology
KEGGhsa:773
Structure
PDB3BXKPDB8X90PDB8X91
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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13GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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42+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Voltage-dependent P/Q-type calcium channel subunit alpha-1A, how selective are they, and which programs against it are still in active trials?

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