Glycine N-methyltransferase

BE0000372ProteinHumansGNMT

Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy), a reaction regulated by the binding of 5-methyltetrahydrofolate. It is acted on by 4 drugs in DrugBank.

Gene name
GNMT
UniProtKB entry
Q14749Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
295 residues · 32,742 Da
Also known as
2.1.1.20

Resolves to

Protein
UniProtQ14749UniProt nameGNMT_HUMAN
Gene
HGNCHGNC:4415NCBI Gene27232GenBank8671584GeneCardsGNMT
Pharmacology
KEGGhsa:27232
Structure
PDB1R74PDB2AZT
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
6GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
21+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Glycine N-methyltransferase, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In