Amidophosphoribosyltransferase

BE0000374ProteinHumansPPAT

Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. It is acted on by 6 drugs in DrugBank.

Gene name
PPAT
UniProtKB entry
Q06203Swiss-Prot
Residues / weight
517 residues · 57,399 Da
Also known as
2.4.2.14 · ATase · Glutamine phosphoribosylpyrophosphate amidotransferase · GPAT

Resolves to

Protein
UniProtQ06203UniProt namePUR1_HUMAN
Gene
HGNCHGNC:9238NCBI Gene5471GenBank219459GeneCardsPPAT
Pharmacology
KEGGhsa:5471
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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5GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Amidophosphoribosyltransferase, how selective are they, and which programs against it are still in active trials?

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