Sodium- and chloride-dependent creatine transporter 1

BE0000375ProteinHumansSLC6A8

Creatine:sodium symporter which mediates the uptake of creatine (PubMed:17465020, PubMed:22644605, PubMed:25861866, PubMed:7945388, PubMed:7953292, PubMed:9882430). It is acted on by 4 drugs in DrugBank.

Gene name
SLC6A8
UniProtKB entry
P48029Swiss-Prot
Cellular location
Cell membrane
Residues / weight
635 residues · 70,522 Da
Also known as
Creatine transporter 1 · CT1 · Solute carrier family 6 member 8

Resolves to

Protein
UniProtP48029UniProt nameSC6A8_HUMAN
Gene
HGNCHGNC:11055NCBI Gene6535GenBank493132GeneCardsSLC6A8
Pharmacology
IUPHAR/GtoPdb934KEGGhsa:6535
Structure
PDB9KR7PDB9KRHPDB9KRI
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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27+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sodium- and chloride-dependent creatine transporter 1, how selective are they, and which programs against it are still in active trials?

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