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Phosphocreatine is a cardioprotective agent indicated for use in cardiac surgery. Phosphocreatine - or creatine phosphate - is the phosphorylated form of creatine.
- Mechanism
- Curator reviewed
Adenosine triphosphate (ATP) is the primary source of chemical energy that body muscles use to perform contractions. During such contraction processes, ATP molecules are depleted as they undergo hydrolysis reactions and become adenosine diphosphate (ADP). To maintain homeostasis in muscle activity, the ATP supply of muscles must be regenerated regularly.
Phosphocreatine occurs naturally within the body and is capable of regenerating ATP by transferring a high-energy phosphate from itself to ADP, resulting in the formation of ATP and creatine. This kind of regeneration of ATP with phosphocreatine typically occurs within seconds of intense muscular or neuronal effort, acting as a quickly accessible reserve of high-energy phosphates for the recycling of ATP in body muscle tissues. ATP recycling from phosphocreatine is in fact known as the quickest form of ATP regeneration.
- Primary indication
- Phosphocreatine is a naturally occuring substance that is found predominantly in the skeletal muscles of vertebrates.Curator reviewed · 1 structured indication
- Formula / weight
- C4H10N3O5P · 211.1131 g/mol (avg)
- Also known as
- Creatine phosphate · Creatine phosphic acid · Creatine-P · Fosfocreatine · N-phosphocreatine
Resolves to
DRBBFCLWYRJSJZ-UHFFFAOYSA-NSMILESCN(CC(O)=O)C(=N)NP(O)(O)=OWhat you can answer from here — as of August 30, 2026
Which drugs share a target with Phosphocreatine, and which of those have an active Phase 3 trial?