Glutamate receptor ionotropic, NMDA 2D

BE0000396ProteinHumansGRIN2D

Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:26875626, PubMed:27616483, PubMed:28126851, PubMed:9489750). It is acted on by 5 drugs in DrugBank.

Gene name
GRIN2D
UniProtKB entry
O15399Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,336 residues · 143,751 Da
Also known as
EB11 · GluN2D · Glutamate [NMDA] receptor subunit epsilon-4 · N-methyl D-aspartate receptor subtype 2D · NMDAR2D

Resolves to

Protein
UniProtO15399UniProt nameNMDE4_HUMAN
Gene
HGNCHGNC:4588NCBI Gene2906GenBank2444026GeneCardsGRIN2D
Pharmacology
KEGGhsa:2906
Structure
PDB7YFFPDB7YFLPDB7YFM
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glutamate receptor ionotropic, NMDA 2D, how selective are they, and which programs against it are still in active trials?

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