Tenocyclidine (TCP, thienyl cyclohexylpiperidine) is a dissociative anesthetic drug with stimulant and hallucinogenic effects. It is more potent than phencyclidine and hence, this drug was classified under the schedule 1...
- Mechanism
- Curator reviewed
The primary interactions are as a non-competitive antagonist at the 3A-subunit of the NMDAR in Homo sapiens. TCP is known to bind, with relatively high affinity, to the D1 subunit of the human DAT, in addition to displaying a positive antagonistic effect at the α7-subunit of the Nicotinic Acetylcholine Receptor (nAChR). It also binds to the mu-opioid receptor, which seems to be a central part of the mechanism of action of drugs in this class. (For example, Dizocilpine MK-801 shows little appreciable analgesic effect despite having a high specificity for the NMDA-3A and NMDA-3B subunits - this may well be mediated by the lack of related efficacy at the mu-opioid receptor, though the NMDAR certainly does play a role in transmission of pain signals).
- Primary indication
- Because of its high affinity for the phencyclidine binding site on the NMDA receptor, the 3H radiolabelled form of tenocyclidine is widely used in research into NMDA receptors.Curator reviewed
- Formula / weight
- C15H23NS · 249.415 g/mol (avg)
Resolves to
JUZZEWSCNBCFRL-UHFFFAOYSA-NSMILESC1CCN(CC1)C1(CCCCC1)C1=CC=CS1What you can answer from here — as of September 23, 2026
Which drugs share a target with Tenocyclidine, and which of those have an active Phase 3 trial?
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