Ornithine decarboxylase

BE0000404ProteinHumansODC1

Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. It is acted on by 13 drugs in DrugBank.

Gene name
ODC1
UniProtKB entry
P11926Swiss-Prot
Residues / weight
461 residues · 51,148 Da
Also known as
4.1.1.17 · ODC

Resolves to

Protein
UniProtP11926UniProt nameDCOR_HUMAN
Gene
HGNCHGNC:8109NCBI Gene4953GenBank29893806GeneCardsODC1
Pharmacology
IUPHAR/GtoPdb1276KEGGhsa:4953
Structure
PDB1D7KPDB2ON3PDB2OO0
Drugs

What you can answer from here — as of September 07, 2019

13DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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4GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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48+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Ornithine decarboxylase, how selective are they, and which programs against it are still in active trials?

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