Carnitine O-palmitoyltransferase 1, liver isoform

BE0000406ProteinHumansCPT1A

Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion (PubMed:11350182, PubMed:14517221, PubMed:16651524,... It is acted on by 3 drugs in DrugBank.

Gene name
CPT1A
UniProtKB entry
P50416Swiss-Prot
Cellular location
Mitochondrion outer membrane
Residues / weight
773 residues · 88,367 Da
Also known as
2.3.1.21 · Carnitine O-palmitoyltransferase I, liver isoform · Carnitine palmitoyltransferase 1A · CPT I · CPT1

Resolves to

Protein
UniProtP50416UniProt nameCPT1A_HUMAN
Gene
HGNCHGNC:2328NCBI Gene1374GenBank755646GeneCardsCPT1A
Pharmacology
KEGGhsa:1374
Structure
PDB2LE3
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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15GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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30+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Carnitine O-palmitoyltransferase 1, liver isoform, how selective are they, and which programs against it are still in active trials?

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