S-adenosylmethionine synthase isoform type-1

BE0000407ProteinHumansMAT1A

Catalyzes the formation of S-adenosylmethionine from methionine and ATP. It is acted on by 4 drugs in DrugBank.

Gene name
MAT1A
UniProtKB entry
Q00266Swiss-Prot
Residues / weight
395 residues · 43,648 Da
Also known as
2.5.1.6 · AdoMet synthase 1 · AMS1 · MAT 1 · MAT-I/III

Resolves to

Protein
UniProtQ00266UniProt nameMETK1_HUMAN
Gene
HGNCHGNC:6903NCBI Gene4143GenBank220066GeneCardsMAT1A
Pharmacology
KEGGhsa:4143
Structure
PDB2OBVPDB6SW5PDB6SW6
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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22+ReferencesStructured and connected to the statements they support
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Which approved drugs act on S-adenosylmethionine synthase isoform type-1, how selective are they, and which programs against it are still in active trials?

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