Intermediate conductance calcium-activated potassium channel protein 4

BE0000415ProteinHumansKCNN4

Intermediate conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin which binds the intracellular calcium allowing its opening (PubMed:10026195, PubMed:10961988, PubMed:11425865, PubMed:15831468,... It is acted on by 6 drugs in DrugBank.

Gene name
KCNN4
UniProtKB entry
O15554Swiss-Prot
Cellular location
Cell membrane
Residues / weight
427 residues · 47,695 Da
Also known as
Gardos channel · hIK1 · hKCa4 · hSK4 · IK1

Resolves to

Protein
UniProtO15554UniProt nameKCNN4_HUMAN
Gene
HGNCHGNC:6293NCBI Gene3783GenBank2584866GeneCardsKCNN4
Pharmacology
IUPHAR/GtoPdb384KEGGhsa:3783
Structure
PDB6CNMPDB6CNNPDB6CNO
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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10GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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33+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Intermediate conductance calcium-activated potassium channel protein 4, how selective are they, and which programs against it are still in active trials?

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