Chlorzoxazone is a drug with muscle relaxant properties that is used as an adjunct to physical therapy and analgesics to treat stiffness and pain caused by a variety of musculoskeletal conditions. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain.
- Mechanism
- Curator reviewed
Chlorzoxazone inhibits degranulation of mast cells, subsequently preventing the release of histamine and slow-reacting substance of anaphylaxis (SRS-A), mediators of type I allergic reactions. Chlorzoxazone also may reduce the release of inflammatory leukotrienes. Chlorzoxazone may act by inhibiting calcium and potassium influx which would lead to neuronal inhibition and muscle relaxation. Data available from animal experiments as well as human study indicate that chlorzoxazone acts primarily at the level of the spinal cord and subcortical areas of the brain where it inhibits multisynaptic reflex arcs involved in producing and maintaining skeletal muscle spasm
- Primary indication
- For the relief of discomfort associated with acute painful musculoskeletal conditions.Curator reviewed · 1 structured indication
- Formula / weight
- C7H4ClNO2 · 169.565 g/mol (avg)
- First approval
- Canada, 2003 · United States, 1958
- Also known as
- 5-chlorobenzoxazolidone · Chlorzoxane
- Code names
- MI 315 · USAF MA-10
- Brand names
Resolves to
TZFWDZFKRBELIQ-UHFFFAOYSA-NSMILESClC1=CC2=C(OC(=O)N2)C=C1What you can answer from here — as of September 13, 2026
Which drugs share a target with Chlorzoxazone, and which of those have an active Phase 3 trial?
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