Serine/threonine-protein kinase A-Raf

BE0000434ProteinHumansARAF

Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. It is acted on by 6 drugs in DrugBank.

Gene name
ARAF
UniProtKB entry
P10398Swiss-Prot
Residues / weight
606 residues · 67,585 Da
Also known as
2.7.11.1 · ARAF1 · PKS · PKS2 · Proto-oncogene A-Raf

Resolves to

Protein
UniProtP10398UniProt nameARAF_HUMAN
Gene
HGNCHGNC:646NCBI Gene369GenBank1340152GeneCardsARAF
Pharmacology
IUPHAR/GtoPdb1933KEGGhsa:369
Structure
PDB1WXMPDB2MSEPDB8VSL
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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27+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Serine/threonine-protein kinase A-Raf, how selective are they, and which programs against it are still in active trials?

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