This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Tovorafenib
DrugBank Accession Number
DB15266
Background

Tovorafenib (TAK-580) is under investigation in clinical trial NCT02723006 (Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of Investigational Treatments in Combination With Standard of Care Immune Checkpoint Inhibitors in Participants With Advanced Melanoma).

Type
Small Molecule
Groups
Investigational
Structure
Weight
Average: 506.29
Monoisotopic: 505.0102337
Chemical Formula
C17H12Cl2F3N7O2S
Synonyms
  • 4-Pyrimidinecarboxamide, 6-amino-5-chloro-N-[(1R)-1-[5-[[[5-chloro-4-(trifluoromethyl)-2-pyridinyl]amino]carbonyl]-2-thiazolyl]ethyl]-
  • 6-Amino-5-chloro-N-((1R)-1-(5-(((5-chloro-4-(trifluoromethyl)-2-pyridinyl)amino)carbonyl)-2-thiazolyl)ethyl)-4-pyrimidinecarboxamide
External IDs
  • BIIB-024
  • BIIB024
  • DAY-101
  • DAY101
  • MLN-2480
  • TAK 580
  • TAK-580

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
ZN90E4027M
CAS number
1096708-71-2
InChI Key
VWMJHAFYPMOMGF-ZCFIWIBFSA-N
InChI
InChI=1S/C17H12Cl2F3N7O2S/c1-6(28-15(31)12-11(19)13(23)27-5-26-12)16-25-4-9(32-16)14(30)29-10-2-7(17(20,21)22)8(18)3-24-10/h2-6H,1H3,(H,28,31)(H2,23,26,27)(H,24,29,30)/t6-/m1/s1
IUPAC Name
6-amino-5-chloro-N-[(1R)-1-(5-{[5-chloro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl}-1,3-thiazol-2-yl)ethyl]pyrimidine-4-carboxamide
SMILES
C[C@@H](NC(=O)C1=C(Cl)C(N)=NC=N1)C1=NC=C(S1)C(=O)NC1=NC=C(Cl)C(=C1)C(F)(F)F

References

General References
Not Available
ChemSpider
28637796
BindingDB
209864
ChEBI
167672
ChEMBL
CHEMBL3348923
ZINC
ZINC000043202464
PDBe Ligand
QOP
PDB Entries
6v34

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3Not Yet RecruitingTreatmentLow Grade Glioma (LGG)1
2Not Yet RecruitingTreatmentRecurrent Langerhans Cell Histiocytosis / Refractory Langerhans cell histiocytosis1
2RecruitingTreatmentChildhood Craniopharyngioma / Postsurgical craniopharyngioma / Recurrent Craniopharyngioma1
2RecruitingTreatmentLow Grade Glioma (LGG) / Solid Tumors, Advanced Solid Tumors1
1Active Not RecruitingTreatmentLow Grade Glioma (LGG)1
1CompletedTreatmentAdvanced Nonhematologic Malignancies1
1CompletedTreatmentMelanoma / Metastatic Melanoma / Neoplastic Disease / Solid Tumors1
1TerminatedOtherMelanoma1
1, 2RecruitingTreatmentMelanoma / Solid Tumors1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00194 mg/mLALOGPS
logP3.15ALOGPS
logP2.99Chemaxon
logS-5.4ALOGPS
pKa (Strongest Acidic)10.29Chemaxon
pKa (Strongest Basic)2.29Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count7Chemaxon
Hydrogen Donor Count3Chemaxon
Polar Surface Area135.78 Å2Chemaxon
Rotatable Bond Count6Chemaxon
Refractivity114.04 m3·mol-1Chemaxon
Polarizability43.95 Å3Chemaxon
Number of Rings3Chemaxon
Bioavailability1Chemaxon
Rule of FiveNoChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleYesChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created at May 20, 2019 15:06 / Updated at December 01, 2022 11:29