Cyclin-dependent kinase 15

BE0000437ProteinHumansCDK15

Serine/threonine-protein kinase that acts like an antiapoptotic protein that counters TRAIL/TNFSF10-induced apoptosis by inducing phosphorylation of BIRC5 at 'Thr-34'. It is acted on by 3 drugs in DrugBank.

Gene name
CDK15
UniProtKB entry
Q96Q40Swiss-Prot
Residues / weight
435 residues · 49,023 Da
Also known as
2.7.11.22 · ALS2CR7 · Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein · Cell division protein kinase 15 · PFTK2

Resolves to

Protein
UniProtQ96Q40UniProt nameCDK15_HUMAN
Gene
HGNCHGNC:14434NCBI Gene65061GenBank15823642GeneCardsCDK15
Pharmacology
KEGGhsa:65061
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cyclin-dependent kinase 15, how selective are they, and which programs against it are still in active trials?

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