Aldo-keto reductase family 1 member C4

BE0000438ProteinHumansAKR1C4

Cytosolic aldo-keto reductase that catalyzes NADPH-dependent reduction of ketosteroids to hydroxysteroids. It is acted on by 8 drugs in DrugBank.

Gene name
AKR1C4
UniProtKB entry
P17516Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
323 residues · 37,067 Da
Also known as
1.1.1.- · 1.1.1.209 · 1.1.1.210 · 1.1.1.51 · 1.1.1.53

Resolves to

Protein
UniProtP17516UniProt nameAK1C4_HUMAN
Gene
HGNCHGNC:387NCBI Gene1109GenBank4261710GeneCardsAKR1C4
Pharmacology
KEGGhsa:1109
Structure
PDB2FVL
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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6Metabolic reactionsDrug transformations it catalyses, substrate to product
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13GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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21+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Aldo-keto reductase family 1 member C4, how selective are they, and which programs against it are still in active trials?

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