25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial

BE0000443ProteinHumansCYP27B1

A cytochrome P450 monooxygenase involved in vitamin D metabolism and in calcium and phosphorus homeostasis. It is acted on by 6 drugs in DrugBank.

Gene name
CYP27B1
UniProtKB entry
O15528Swiss-Prot
Cellular location
Mitochondrion membrane
Residues / weight
508 residues · 56,503 Da
Also known as
1.14.15.18 · 25-hydroxyvitamin D(3) 1-alpha-hydroxylase · 25-OHD-1 alpha-hydroxylase · Calcidiol 1-monooxygenase · CYP1ALPHA

Resolves to

Protein
UniProtO15528UniProt nameCP27B_HUMAN
Gene
HGNCHGNC:2606NCBI Gene1594GenBank2612976GeneCardsCYP27B1
Pharmacology
IUPHAR/GtoPdb1370KEGGhsa:1594
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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5Metabolic reactionsDrug transformations it catalyses, substrate to product
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22GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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28+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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