Solute carrier family 13 member 2

BE0000447ProteinHumansSLC13A2

Low-affinity sodium-dicarboxylate cotransporter, that mediates the entry of citric acid cycle intermediates, such as succinate, citrate, fumarate and alpha-ketoglutarate (2-oxoglutarate) into the small intestine and renal proximal tubule (PubMed:10894787, PubMed:8967342, PubMed:9668069, PubMed:38552027). It is acted on by 2 drugs in DrugBank.

Gene name
SLC13A2
UniProtKB entry
Q13183Swiss-Prot
Cellular location
Apical cell membrane
Residues / weight
592 residues · 64,409 Da
Also known as
Na(+)/dicarboxylate cotransporter 1 · NaDC-1 · NADC1 · Renal sodium/dicarboxylate cotransporter · SDCT1

Resolves to

Protein
UniProtQ13183UniProt nameS13A2_HUMAN
Gene
HGNCHGNC:10917NCBI Gene9058GenBank1098557GeneCardsSLC13A2
Pharmacology
KEGGhsa:9058
Structure
PDB8W6CPDB8W6DPDB8W6G
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Solute carrier family 13 member 2, how selective are they, and which programs against it are still in active trials?

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