Glutamate receptor ionotropic, NMDA 2C

BE0000454ProteinHumansGRIN2C

Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:26875626, PubMed:36309015). It is acted on by 5 drugs in DrugBank.

Gene name
GRIN2C
UniProtKB entry
Q14957Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,233 residues · 134,208 Da
Also known as
GluN2C · Glutamate [NMDA] receptor subunit epsilon-3 · N-methyl D-aspartate receptor subtype 2C · NMDAR2C · NR2C

Resolves to

Protein
UniProtQ14957UniProt nameNMDE3_HUMAN
Gene
HGNCHGNC:4587NCBI Gene2905GenBank1196449GeneCardsGRIN2C
Pharmacology
IUPHAR/GtoPdb458KEGGhsa:2905
Structure
PDB8E92PDB8E93PDB8E94
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glutamate receptor ionotropic, NMDA 2C, how selective are they, and which programs against it are still in active trials?

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